The Sebae Anemone is a delicate anemone, and easily damaged. It can be difficult to acclimate, so its care should only be attempted by the most experienced aquarists. It prefers to have a sandy substrate allowing its base to be hidden from sight. It should not be placed on a rock. It requires strong lighting, moderate water flow, porous live rock, and a variety of sandy and rocky locations from which it can choose to live. The addition of a Clownfish such as the Clarki Clown,
Amphiprion clarki, can help it acclimate to the tank and ensure its general well being. It is a moderately difficult anemone to care for, but once acclimated, it can be very hardy.
It requires a diet of fish, worms, clams, shrimp, and other meaty foods once a week.